"It is with extraordinary sadness we can confirm the death of our friend and colleague, Anthony Bourdain," the network said in a statement Friday morning. "His love of great adventure, new friends, fine food and drink and the remarkable stories of the world made him a unique storyteller.
"His talents never ceased to amaze us and we will miss him very much. Our thoughts and prayers are with his daughter and family at this incredibly difficult time."
Bourdain joined CNN five years ago. In an email to employees, the network's president, Jeff Zucker, remembered him as an "exceptional talent."
"Tony will be greatly missed not only for his work but also for the passion with which he did it," Zucker wrote.
Viewers around the world felt connected to Bourdain through his fearless travels, his restless spirit and his magical way with words. Fans, fellow chefs, celebrities and friends reacted to his death with stunned sorrow.
"My heart breaks for Tony Bourdain," CNN's chief international correspondent, Christiane Amanpour, wrote on Twitter. "May he rest in peace now"