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Thread: Study: Ivermectin doesn't reduce risk of severe disease in patients with COVID and comorbidities

  1. #1

    Study: Ivermectin doesn't reduce risk of severe disease in patients with COVID and comorbidities

    Question
    Does adding ivermectin, an inexpensive and widely available antiparasitic drug, to the standard of care reduce the risk of severe disease in patients with COVID-19 and comorbidities?

    Findings
    In this open-label randomized clinical trial of high-risk patients with COVID-19 in Malaysia, a 5-day course of oral ivermectin administered during the first week of illness did not reduce the risk of developing severe disease compared with standard of care alone.

    Meaning
    The study findings do not support the use of ivermectin for patients with COVID-19.

    Results
    Among 490 patients included in the primary analysis (mean [SD] age, 62.5 [8.7] years; 267 women [54.5%]), 52 of 241 patients (21.6%) in the ivermectin group and 43 of 249 patients (17.3%) in the control group progressed to severe disease (relative risk [RR], 1.25; 95% CI, 0.87-1.80; P = .25). For all prespecified secondary outcomes, there were no significant differences between groups. Mechanical ventilation occurred in 4 (1.7%) vs 10 (4.0%) (RR, 0.41; 95% CI, 0.13-1.30; P = .17), intensive care unit admission in 6 (2.4%) vs 8 (3.2%) (RR, 0.78; 95% CI, 0.27-2.20; P = .79), and 28-day in-hospital death in 3 (1.2%) vs 10 (4.0%) (RR, 0.31; 95% CI, 0.09-1.11; P = .09). The most common adverse event reported was diarrhea (14 [5.8%] in the ivermectin group and 4 [1.6%] in the control group).

    Conclusions and Relevance
    In this randomized clinical trial of high-risk patients with mild to moderate COVID-19, ivermectin treatment during early illness did not prevent progression to severe disease. The study findings do not support the use of ivermectin for patients with COVID-19.

    Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial | Complementary and Alternative Medicine | JAMA Internal Medicine | JAMA Network

  2. #2
    So if the Son sets you free, you will be free indeed. John's Avatar
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    Quote Originally Posted by njtom View Post
    Question
    Does adding ivermectin, an inexpensive and widely available antiparasitic drug, to the standard of care reduce the risk of severe disease in patients with COVID-19 and comorbidities?

    Findings
    In this open-label randomized clinical trial of high-risk patients with COVID-19 in Malaysia, a 5-day course of oral ivermectin administered during the first week of illness did not reduce the risk of developing severe disease compared with standard of care alone.

    Meaning
    The study findings do not support the use of ivermectin for patients with COVID-19.

    Results
    Among 490 patients included in the primary analysis (mean [SD] age, 62.5 [8.7] years; 267 women [54.5%]), 52 of 241 patients (21.6%) in the ivermectin group and 43 of 249 patients (17.3%) in the control group progressed to severe disease (relative risk [RR], 1.25; 95% CI, 0.87-1.80; P = .25). For all prespecified secondary outcomes, there were no significant differences between groups. Mechanical ventilation occurred in 4 (1.7%) vs 10 (4.0%) (RR, 0.41; 95% CI, 0.13-1.30; P = .17), intensive care unit admission in 6 (2.4%) vs 8 (3.2%) (RR, 0.78; 95% CI, 0.27-2.20; P = .79), and 28-day in-hospital death in 3 (1.2%) vs 10 (4.0%) (RR, 0.31; 95% CI, 0.09-1.11; P = .09). The most common adverse event reported was diarrhea (14 [5.8%] in the ivermectin group and 4 [1.6%] in the control group).

    Conclusions and Relevance
    In this randomized clinical trial of high-risk patients with mild to moderate COVID-19, ivermectin treatment during early illness did not prevent progression to severe disease. The study findings do not support the use of ivermectin for patients with COVID-19.

    Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities: The I-TECH Randomized Clinical Trial | Complementary and Alternative Medicine | JAMA Internal Medicine | JAMA Network
    If you get Covid you don't have to take it.

    Funny thing though, the same study references success with Ivermectin.

    To our knowledge, there are no approved treatments for individuals with mild to moderate
    SARS-CoV-2 infection to prevent progression to severe disease. Ivermectin may be
    beneficial in this setting and potentially leads to lower morbidity and mortality in high-risk
    patients. A meta-analysis of 18 RCTs in 2282 patients with Covid-19 showed a 75%
    improvement in survival, faster time to recovery and signs of a dose dependent effect of
    viral clearance for patients given ivermectin versus control treatment.
    https://cdn.jamanetwork.com/ama/cont...5G5CRDK6RD3PGA

  3. #3
    Senior Member Pentecali's Avatar
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    No one is forced at gun point to take it, but I'm a living witness it helped me and numerous family and friends, some who would have ended up in very serious condition otherwise.

    It's been prescribed to humans for many years. Suddenly, it's unsafe and only for horses. We bought loads of it in pill form for human consumption. Livestock are given larger liquid dosages with a syringe.

    It's very cheap which make you wonder ..


    It may not help everyone, but the vents didn't save everyone either, nor the drug Remdesivir that was given to a lot of patients.

    But everyone who wants to go on a vent should have that option too.

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  5. #4
    Quote Originally Posted by Pentecali View Post
    No one is forced at gun point to take it, but I'm a living witness it helped me and numerous family and friends, some who would have ended up in very serious condition otherwise.

    It's been prescribed to humans for many years. Suddenly, it's unsafe and only for horses. We bought loads of it in pill form for human consumption. Livestock are given larger liquid dosages with a syringe.

    It's very cheap which make you wonder ..


    It may not help everyone, but the vents didn't save everyone either, nor the drug Remdesivir that was given to a lot of patients.

    But everyone who wants to go on a vent should have that option too.
    Regarding whether the drug is safe, the study does not say that it was unsafe, it only says that it didn't have any statistically significant benefit for the "high risk" patients who participated in the study. So if you're happy to take it, then no problem from my side.

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  7. #5
    So if the Son sets you free, you will be free indeed. John's Avatar
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    Quote Originally Posted by njtom View Post
    Regarding whether the drug is safe, the study does not say that it was unsafe, it only says that it didn't have any statistically significant benefit for the "high risk" patients who participated in the study. So if you're happy to take it, then no problem from my side.
    I don't think anyone has claimed Ivermectin only to be a successful protocol. It's always Iverctin + +, zinc, z-pack, etc. They did a study on HCQ "only" and had the same result so yeah they are willing to kill people to prove a worthless point, more ghoulish nonsense.

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