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Thread: University of Michigan study: Existing drugs block, reduce COVID in cells

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    University of Michigan study: Existing drugs block, reduce COVID in cells

    ANN ARBOR – Researchers at the University of Michigan have found several FDA-approved drugs and compounds are effective in blocking or reducing SARS-CoV-2 in cells.

    The study was conducted as researchers around the world scramble to discover treatments for COVID-19, according to a U-M release. While vaccines are the best defense in preventing the disease, therapies to treat it are in short supply.

    For the study, researchers treated cells with 1,400 drugs and compounds, both before and after infection. Upon screening the cells, they had 17 potential hits, ten of which were newly recognized, while seven -- including remdesivir -- had already previously been identified in drug repurposing studies.

    Recently published in the "Proceedings of the National Academy of Sciences," the study used image analysis of human cell lines powered by artificial intelligence during active COVID infections.

    Using various types of cells, the researchers confirmed the 17 candidate compounds. In order to mimic a COVID infection in the respiratory tract, the team tested human lung cells that were stem-cell derived. Of the 17 compounds, nine demonstrated anti-viral activity, including a protein that's available over the counter as a dietary supplement and is also found in human breastmilk called lactoferrin.

    "We found lactoferrin had remarkable efficacy for preventing infection, working better than anything else we observed," Sexton said in a release.

    He said the effectiveness of the supplement extends to variants, including the delta variant, according to early data...

    University of Michigan study: Existing drugs block, reduce COVID in cells

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