Thread: Common, Cheap Treatment Prevents and Cures COVID-19 - Wuhan Virus

Thanks
There are doing a lot of studies , and it will take some time to get solid results.
There is also containdications to observe.

Originally Posted by tschau

Thanks
There are doing a lot of studies , and it will take some time to get solid results.
There is also containdications to observe.

If it's cheap and there are next to no side effects then it's snobbery to postpone using it even if the effect is mild.

Originally Posted by njtom

Looks like the results (which are mixed) of a few small studies are coming in.

No Evidence of Rapid Antiviral Clearance or Clinical Benefit with the Combination of Hydroxychloroquine and Azithromycin in Patients with Severe COVID-19 Infection - ScienceDirect

The COVID-19 epidemic is the worst worldwide pandemic in a century with more than 500,000
cases and 25,000 deaths so far. In France, more than 30,000 cases have been reported up to
March 27, and nearly 2,000 have died.

Pending the availability of a vaccine, there is a critical need to identify effective treatments
and a number of clinical trials have been implemented worldwide.

Chloroquine analogs have been shown to inhibit the acidification of endosomes and to exhibit
in vitro a non specific antiviral activity at high micromolar concentration against a broad range
of emerging virus (HIV, dengue, hepatitis C, chikungunya, influenza, Ebola, SARS and MERS
viruses) and more recently COVID-19 (1-2).

In France, following the results of a clinical study in Marseille, there is considerable interest
for the use of hydroxychloroquine to treat COVID-19 disease, and the French Ministry of
Health recently allowed the use of hydroxychloroquine to treat COVID-19 disease pending the
results of ongoing clinical trials (3).

In their study, Gautret et al. reported a 100% viral clearance in nasopharyngeal swabs in 6
patients after 5 and 6 days of the combination of hydroxychloroquine and azithromycin (3).

This rate of viral clearance was lower with hydroxychloroquine alone (57.1%) and was only
12.5% in patients who did not receive hydroxychloroquine (p< 0.001).

Such a rapid and full viral clearance was quite unexpected and we wished to assess in a
prospective study virologic and clinical outcomes of 11 consecutive patients hospitalized in
our department who received hydroxychloroquine (600 mg/d for 10 days) and azithromycin
(500 mg Day 1 and 250 mg days 2 to 5) using the same dosing regimen reported by Gautret et
al. (3).

There were 7 men and 4 women with a mean age of 58.7 years (range: 20-77), 8 had significant
comorbidities associated with poor outcomes (obesity: 2; solid cancer: 3; hematological
cancer: 2; HIV-infection: 1).

At the time of treatment initiation, 10/11 had fever and received nasal oxygen therapy. Within
5 days, one patient died, two were transferred to the ICU. In one patient, hydroxychloroquine
and azithromycin were discontinued after 4 days because of a prolongation of the QT interval
from 405 ms before treatment to 460 and 470 ms under the combination. Mean through
blood concentration of hydroxychloroquine was 678 ng/mL (range: 381-891) at days 3-7 after
treatment initiation.

Repeated nasopharyngeal swabs in 10 patients (not done in the patient who died) using a
qualitative PCR assay (nucleic acid extraction using Nuclisens Easy Mag®, Biomerieux and
amplification with RealStar SARS CoV-2®, Altona), were still positive for SARS-CoV2 RNA in
8/10 patients (80%, 95% confidence interval: 49-94) at days 5 to 6 after treatment initiation.

These virologic results stand in contrast with those reported by Gautret et al. and cast doubts
about the strong antiviral efficacy of this combination. Furthermore, in their report Gautret et
al also reported one death and three transfers to the ICU among the 26 patients who received
hydroxychloroquine, also underlining the poor clinical outcome with this combination.

In addition, a recent study from China in individuals with COVID-19 found no difference in the
rate of virologic clearance at 7 days with or without 5 days of hydroxychloroquine, and no
difference in clinical outcomes (duration of hospitalization, temperature normalization,
radiological progression) (4). These results are consistent with the lack of virologic or clinical
benefit of chloroquine in a number of viral infections where it was assessed for treatment or
prophylaxis with sometimes a deleterious effect on viral replication (5-8).

In summary, despite a reported antiviral activity of chloroquine against COVID-19 in vitro, we
found no evidence of a strong antiviral activity or clinical benefit of the combination of
hydroxychloroquine and azithromycin for the treatment of our hospitalized patients with
severe COVID-19. Ongoing randomized clinical trials with hydroxychloroquine should provide
a definitive answer regarding the alleged efficacy of this combination and will assess its safety.

That's the political trial. The Chinese/Left wing will bend over backwards to prevent a solution, Trump BAD.

Originally Posted by tschau

Thanks
There are doing a lot of studies , and it will take some time to get solid results.
There is also containdications to observe.

>> There are doing a lot of studies

Indeed.

Originally Posted by Colonel

If it's cheap and there are next to no side effects then it's snobbery to postpone using it even if the effect is mild.

Well, if I were suffering from the disease, I would ask my doctor to
at least consider it.

Originally Posted by Colonel

If it's cheap and there are next to no side effects then it's snobbery to postpone using it even if the effect is mild.

yes, but they have already seen side effects and , as far as I know, 3 people have died from the side effects

hey are testing also other treatements here, like getting antibodies from the blood of people who have overcame Covid-19. Tomorrrow a second big hospital here will work on that, and they think that this could be a good way

Originally Posted by tschau

yes, but they have already seen side effects and , as far as I know, 3 people have died from the side effects

From hydrochloroquine ? More people die from vaccines, the real question is how many lives they save. Nothing is perfect.

Dr Smith with about 80 patients with this Coronavirus confirms they have been using Hydroxychloroquine and it is a "game changer".

Video at the link

Ingraham's 'Medicine Cabinet' on effectiveness of hydroxychloroquine, whether diabetes increases COVID-19 risk

Originally Posted by tschau

They are testing also other treatements here, like getting antibodies from the blood of people who have overcame Covid-19.

I've been wondering if they had any tests to check if someone already had it. Here in Michigan there are suddenly a lot of cases and hospitalizations and there is a theory that Michigan might have had the virus starting back in December or January but no one knew it yet so no precautions were put in place.

I think it was in late January that I started getting some weird symptoms, a little sore throat, a little achy, a lot of chills (never took my temp), chest congestion, a dry lingering cough, getting short of breath just carrying laundry. I almost never take naps but by late afternoons I would crawl under the covers to warm up and would fall asleep for an hour or two.

It was nothing severe just kind of tiresome because whatever it was that tried to mess with me lingered for a few weeks. Was it just a common bug or something more...dunno. I am abiding by the regulations for self distancing but it would be nice to know if there's a way to find out who is immune to it now.